Textbook of Ricin Toxins

Ricin toxins are highly potent protein toxins derived from the castor bean plant, Ricinus communis. They are classified as ribosome-inactivating proteins (RIPs) due to their ability to inhibit protein synthesis within cells. Ricin consists of two subunits, A and B: the B subunit facilitates cellular entry by binding to cell surface receptors, while the A subunit acts enzymatically to disrupt protein synthesis, leading to cell death. Ricin-based vaccines are being studied for immunization against ricin poisoning. Additionally, ricin-based immunotoxins have been investigated for treating diseases like HIV. These immunotoxins could potentially destroy infected cells or reduce viral reservoirs. Despite its danger, ricin is also studied for potential medical applications, such as targeted cancer therapy. Understanding its mechanisms and developing antidotes remains crucial for both defense and therapeutic purposes. This book is compiled in such a manner, that it will provide in-depth knowledge about the theory and applications of ricin toxin in medicine. It is a compilation of chapters that discuss the most vital concepts and emerging trends in the field of toxicology. This book is meant for students who are looking for an elaborate reference text on toxins.