This book integrates aspects of computational materials science, physical metallurgy, alloy design, structure-properties relationships, and applications of advanced multicomponent alloys. It can serve as a textbook for courses on advanced structural and functional materials for undergraduate and graduate students. Notably, the book compiles cutting-edge research on the progress of materials science of multicomponent alloys from fundamentals to engineering applications. It can be of considerable interest for researchers and scientists in the field of materials science and engineering, mechanical engineering, and metallurgy engineering. In addition, this book not only summarizes the compositions, properties, and applications of various types of multicomponent alloys but also presents a complete idea on the efficient design of materials and processes to satisfy targeted performance in materials and structures. Thus, it can also be used as a reference book for engineers and researchers in industries.