Hptlc Method

This title is printed to order. This book may have been self-published. If so, we cannot guarantee the quality of the content. In the main most books will have gone through the editing process however some may not. We therefore suggest that you be aware of this before ordering this book. If in doubt check either the author or publisher’s details as we are unable to accept any returns unless they are faulty. Please contact us if you have any questions.

A stability-indicating high-performance thin-layer chromatography (HPTLC) method was developed and validated for determination of Vibegron. Optimization of conditions for the spectro densitometric procedure was reached by eluting HPTLC pre-coated silica gel aluminium plates in horizontal chamber. The solvent system consisted of Acetone. This system was found to give compact, dense and typical peak for Vibegron. Densitometric analysis of the drug was carried out in the reflectance mode at 254 nm by using a computer controlled densitometric scanner. The calibration curve Vibegron was linear in the range of 200-1000 ng/band. The method was validated for precision, robustness and recovery. Vibegron was subjected for stability study at acid, base, oxidation, thermal and photo- degradation condition, among which thermal degradation had the highest degradative.