Angiotensin and the Heart

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ACE inhibitors are a cornerstone of cardiovascular drug therapy. Beneficial effects in patients with hypertension, heart failure and post myocardial infarction have been established in large clinical trials. In parallel, experimental research has shifted interest from the immediate homeostatic function of the circulating renin-angiotensin system to the multiple paracrine functions of local tissue renin-angiotensin systems. This book gives a complete and current overview of the most recent findings on the role of angiotensin and associated mediators in cardiovascular adaptation and disease, with a particular emphasis of the treatment of such disease by ACE inhibitors.