Collagen: Basis of Life

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In life’s long march from the primordial ooze, anything with more than one cell- from the simplest, oldest living creature to man- is knitted into whatever it is by collagen. Collagens are fascinating proteins not only because they are unique in structure and function, but also because of their ubiquitous distribution throughout the animal kingdom. Knowledge of the structure, biosynthesis and interactions with other components, its regulation and degradation mechanisms and changes it undergoes with age is therefore essential, for the understanding of the functioning of the tissues. As we know that how important blood is to an organism, but few of us are aware that as an organism, we are literally swimming in collagen. The fibrous fluid, in which our tissues are submerged, is actually collagen. We may say that nature had to invent collagen for the evolutionary march upward from a single cell.