Cancer Therapy: Differentiation, Immunomodulation and Angiogenesis

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Provided here is a comprehensive examination of the basic and clinical

condition of three innovative and promising approaches to cancer therapy,
which may support or even substitute chemotherapy: differentiation,

immunomodulation, and inhibition of angiogenesis. Differentiation shouldnormalize neoplastic cells and make them compatible with the host. Its

feasibility with retinoids, interferons, chemotherapeutic and other agents is discussed. Modulation by biological agents, cytotoxic effector cells and drugs is considered in attempts to boost endogenous antitumour defenses and/or to render neoplastic cells more susceptible to the immune attack

of the host. Finally, the important aspect of interfering with tumour
blood vessel development and function is taken into account. Consideringthe importance that chemotherapy has in cancer treatment and in view of a
more and more integrated strategy, the relationship between the

aforementioned approaches and chemotherapeutic agents and

chemoresistance is treated in detail.