Membrane Defenses Against Attack by Complement and Perforins

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In this volume a comprehensive review of membrane proteins that regulate

complement and perforin-mediated cytolysis is presented. A detailed analysisis provided of the biochemical, molecular, and functional features of

these proteins; the glycosyl phosphatidylinositol linked proteins are
covered, with emphasis placed on the functional importance of this type of membrane anchor. Further chapters include reviews of the effects of

complement activation on cells that are metabolically active, and of the

regulation of cell killing by cytotoxic lymphocytes, considering

the similarities and disparities between the complement and perforin

systems. The therapeutic use of recombinant CR1 for immune-mediated

pathophysiological processes is discussed in a separate section.