Immunotherapy of Renal Cell Carcinoma: Clinical and Experimental Developments

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Advanced renal cell carcinoma is resistant to nearly all forms of systematic therapy. For this reason the last decade has seen numerous research groups working on immunotherapeutic strategies. Immunotherapy of Renal Cell Carcinoma reports the contributions of most of the world’s leading research groups to two international conferences on the immunobiology of this illness. 16 chapters divided into experimental and clinical studies provide an overview of immunotherapy in renal cell carcinoma and a discussion of new laboratory approaches to this topic. The scope of subjects ranges from basic studies of oncogenes and MDRI gene expression, experimental metastases, radio-immunoconjugates, TIL-and LAK-cells, monoclonal antibodies to clinical trials with Interferon, Tumour Necrosis Factor and Interleukin-2. This book will be of interest to clinicians and researchers working in the areas of urology, pathology, medical oncology and radiotherapy. For basic scientists it will be a source of information on clinical aspects of this disease; for clinicians it will provide a review of the current achievements of basic research in the field of immunology and immunotherapy of renal cell carcinoma.