Dead Ends and Detours: Direct Ways to Successful Total Synthesis

A plethora of publications provide valuable information for the organic chemist, yet the results are almost always based on successful reactions. However, a chemist’s life is unfortunately not that easy. On the contrary, trial and error is still one of the most commonly used methods. Thus it would be useful to have access to those syntheses that do not work, since they also provide important results of great importance for further synthesis. This long-awaited book by M. A. Sierra and M. C. de la Torre fills just such a gap. Using major total syntheses they explain the most varied problems and recommend ways out of such dilemmas: Problems at the start and end of a synthesis, difficult and unexpected reactivities of functional groups, problems due to steric properties and much more. The result is a true wealth of information for any organic chemist. The essential tool for successful total synthesis.