Identification and validation of drug targets from bacterial genomes

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In the initial stages of drug therapy, scientists and medical researchers were not aware about the targets on which these antibiotics act. Only thing that fascinated them was that these newly discovered compounds exhibited reasonable antibacterial properties. The above scientific findings propelled to isolate those compounds and use them for treating bacterial diseases. Alexander Fleming's discovery of antibiotic 'Penicillin' is considered as one of the historical milestones in medical research. The following are some of his words summarizing the findings (BMJ, 1955).