When Nanakorobi Nene, a cybernetically-enhanced girl-next-door, heads to the island metropolis of Cenancle to live with her aunt, she has no way of knowing what's in store for her. A chance meeting intertwines her fate with that of the super-rich inventor, Uzal Delilah, and her adorable and grumpy companion, Clarion, who happens to be a cyborg just like Nene.

Nene is thrilled to make a friend, but there's more to Uzal and Clarion-and the island of Cenancle itself-than meets the eye. When a super-powered terrorist threatens Cenancle, Uzal claims that the only way to avert disaster is for Nene to team up with Clarion and use their combined powers-abilities Nene never even knew she had!