Counseling interventions are a proven and powerful way to help individuals with HIV cope with the enormous changes in their lives. Proposing an innovative model for HIV clinical work, this well-organized guide integrates empirical research on the psychosocial aspects of HIV with extensive case material. It describes how to assess clients’ psychosocial concerns and implement interventions to facilitate adjustment; reviews medical and neurocognitive aspects of HIV disease progression; explores the psychotherapeutic context of HIV clinical work; and addresses risk reduction and prevention.