Dr. Big is the imaginary adversary of Reed Gladstone, a teenager who is unwillingly shipped off to summer camp by his parents. While there, he must deal with Butch, a bully from his own neighborhood, and the strange and sinister camp commandant, Ms. Rita Flot. Our hero encounters VIPER, a gang of international criminals that is using the summer camp as a front for its illicit activities. As his alter-ego, Dr. Big, Reed drafts Butch to join him as an agent of GHOST, an international peace-keeping organization working to defeat VIPER before it starts World War III. But not before Reed and Butch have some hair-raising adventures along the way.