Homocysteine Metabolism: From Basic Science to Clinical Medicine

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To date, evidence strongly supports the hypotheses that hyperhomocysteinemia is a strong independent determinant of vascular disease, and that many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins. The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. This wide-ranging treatise on homocysteine covers the topic from the basic biochemical, metabolic, genetic and dietary determinants to disease relationships, including concepts of pathogenesis. It also describes the public-health implications of these associations.