Cellular and Molecular Toxicology: Volume 14, (9780444508683) — Readings Books

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Home / Cellular and Molecular Toxicology: Volume 14
Cellular and Molecular Toxicology: Volume 14
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Cellular and Molecular Toxicology: Volume 14

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Preface.
Contributors to Volume 14.

Introductio n.
1. Basic Concepts.
Introduct ion to molecular toxicology.
Exposure-Dose-Response: a molec ular perspective.
Receptor theory and the ligand-macromolecu le complex.
Control of gene expression.

  1. Xenobiotic Receptor Systems.
    Introduction and ov erview.
    The Per-Arnt-Sim (PAS) protein superfamily.
    The Aryl hydrocarbon receptor: a model of gene-environment interacti ons. Peroxisomes, peroxisome proliferators and peroxisome pro liferator-activated receptors (PPARs).
    The physiological rol e of Pregnane-X-Receptor (PXR) in xenobiotic and bile acid homeostasis.
    Regulation of phenobarbital responsiveness via the Constitut ive Androstane Receptor (CAR). Mechanisms of metal-induction of metallothionein gene expression.
    Modulation of soluble re ceptor signaling by coregulators.
    Convergence of multiple nu clear receptor signaling pathways in the mediation of xenobiotic-induced
Read More
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Format
Hardback
Publisher
Elsevier Science & Technology
Country
United States
Date
14 February 2002
Pages
660
ISBN
9780444508683

Preface.
Contributors to Volume 14.

Introductio n.
1. Basic Concepts.
Introduct ion to molecular toxicology.
Exposure-Dose-Response: a molec ular perspective.
Receptor theory and the ligand-macromolecu le complex.
Control of gene expression.

  1. Xenobiotic Receptor Systems.
    Introduction and ov erview.
    The Per-Arnt-Sim (PAS) protein superfamily.
    The Aryl hydrocarbon receptor: a model of gene-environment interacti ons. Peroxisomes, peroxisome proliferators and peroxisome pro liferator-activated receptors (PPARs).
    The physiological rol e of Pregnane-X-Receptor (PXR) in xenobiotic and bile acid homeostasis.
    Regulation of phenobarbital responsiveness via the Constitut ive Androstane Receptor (CAR). Mechanisms of metal-induction of metallothionein gene expression.
    Modulation of soluble re ceptor signaling by coregulators.
    Convergence of multiple nu clear receptor signaling pathways in the mediation of xenobiotic-induced
Read More
Format
Hardback
Publisher
Elsevier Science & Technology
Country
United States
Date
14 February 2002
Pages
660
ISBN
9780444508683

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