Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.
