The Biochemistry of the Nucleic Acids

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The structure of the nucleic acids; genomes of eukaryotes, bacteria and viruses - chromosome organization; degradation and modification of nucleic acids; the metabolism of nucleotides; replication of DNA; DNA damage, repair and recombination; the arrangement of genes; RNA biosynthesis; control of transcription; processing of RNA transcripts and its control; the translation of mRNA - protein synthesis. Appendices: occurrence and chemical analysis; isolation and separation of nucleic acids; hybridization of nucleic acids; methods of labelling nucleic acids; determination of nucleic acid sequences; cloning DNA; analysis and manipulation of cloned DNA.