Transplanted from Boston to rough-around-the-edges Colorado Springs, Dr. Michaela Mike Quinn (Jane Seymour) faced an uphill battle adapting to her new surroundings and convincing her neighbours to accept a female physician. With the initial adjustment behind her, this superb collection see Mike growing into life on the frontier, raising her three adopted children, trying to maintain her convictions, the health of the town and her new young baby to new husband, Sully.