While the Bubonic Plague spread across Europe during the middle ages slaughtering millions indiscriminately, a young Italian girl becomes a powerful vampire and starts killing without remorse every mortal she encounters. After meeting a werewolf in the catacombs of Paris, they become allies in order to defeat a powerful werewolf out of Germany and his massive werewolf pack intent on dominating the world of mankind for a food source. after creating her first vampire child, they embark for Great Britain before traveling across the ocean to America.