Extracellular Hsp90α in Diabetic Wound Healing
Kathryn O'Brien
Extracellular Hsp90α in Diabetic Wound Healing
Kathryn O'Brien
This title is printed to order. This book may have been self-published. If so, we cannot guarantee the quality of the content. In the main most books will have gone through the editing process however some may not. We therefore suggest that you be aware of this before ordering this book. If in doubt check either the author or publisher’s details as we are unable to accept any returns unless they are faulty. Please contact us if you have any questions.
Chronic and non-healing skin wounds represent a significant clinical, economic and social problem in both developing and developed countries. There are few effective treatments. The lack of relevant animal models to gain insights into the mechanism of human wound healing and, therefore, to identify new and more effective therapeutic targets remains a major challenge. While pig wound healing is considered closest to human wound healing, standardized pig models with demonstrated validity for new therapeutic studies are needed. This report is a systematic evaluation and establishment of both a normal and a diabetic pig wound healing model. We show similar histological changes taking place in diabetic pig and human skin and demonstrate a strong correlation between the duration of diabetic conditions and the length of delay in wound healing. We demonstrate the effectiveness of recombinant Hsp90 protein, to promote both acute and diabetic wound healing in these pig models. More importantly, we have narrowed down the minimum therapeutic entity of secreted Hsp90 to a 27 amino acid peptide. Also, two amino acids of Hsp90 are shown to be important to the migration of skin cells in vitro.
This item is not currently in-stock. It can be ordered online and is expected to ship in 7-14 days
Our stock data is updated periodically, and availability may change throughout the day for in-demand items. Please call the relevant shop for the most current stock information. Prices are subject to change without notice.
Sign in or become a Readings Member to add this title to a wishlist.