This work examines how the changes in social and religious experiences and in attitudes toward substance use observed among young adults are related to changes in substance use, family transitions, living arrangements, college experience and employment. The research uses a variety of analysis techniques and is based on the nationwide Monitoring the Future surveys of more than 38,000 young people followed from high school into adulthood. The research covers the last quarter of the 20th century, a period when drug use and views about drugs underwent many important changes. Specific questions addressed include the following: As young adults experience new freedoms and responsibilities, do their attitudes about drugs change?; Do their religious views and behaviours shift?; Do their new freedoms and responsibilities affect the amount of time they spend in social activities, including going to parties and bars?; And how are any of these changes linked to changes in cigarette use, alcohol use, marijuana use, and cocaine use?