PART 1. SETTING THE SCENE Introduction. Essential biolo gy of stem cell transplantation

PART 2. THE ROLE OF STEM CELL TRANSPLANTATION IN TREATMENT Acute myeloid leukaemia. Chro nic myeloid leukaemia. Acute lymphoblastic leukemia in adults. Childhood leukemias. The myelodysplastic syndromes. Multiple myeloma. Hodgkin?s d isease and non-Hodgkin’s lymphoma. Chronic lymphocytic leukaemia. Solid tumors in children. Breast cancer. Solid tumors in adults. Germ cell tum ors. Primary immunodeficiency diseases. Acquired aplastic anemia and Fan coni anemia. Thalassaemia and sickle cell disease. Lysosomal storage dis orders. Autoimmune disorders

PART 3. PREPARATION FOR TRA NSPLANT Patient selection: preliminary interview, screening of apient and donor. Stem cell donor registries. Cord blood banks and umbil ical cord blood transplantation in children and adults. Human leukocyte antigen matching, compatibility testing and donor selection. Collection and processing of marrow and blood hematopoietic stem cells. Vascular ac cess. High-dose regimens for autologous stem cell transplantation. Myelo utologous stem cell transplantation. Myeloablative conditioning regimens