A Week in the Life of Us follows eight girlsa first week as high school freshman. Zowie has just begun dating her crush Jeremy, but is hassled by his ex-girlfriend. Jaime is disturbed that her best friend Kelly is drifting away. Kelly is a competitive swimmer and also newly craves the attention of boys. Angela is tough and mouthy because she is bored with life and longs for new things to happen. Jessi experiences her first areala boyfriend only to find that things may not be as great as they seem. Crystal is coping with the recent death of her mother, her fatheras depression, and the consequences it has on the rest of her family. Dana resents her father who never looked back after the divorce, until he began to date a much younger woman. And lastly, Louise is the new girl at school who yearns to make friends with these girls.