This book describes the first Prindles to arrive in Clinton and Franklin Counties, NY and follows their descendants through about five generations. Ephraim Prindle, born circa 1755 arrived in Clinton County, NY by the time the 1800 Federal census was taken; and he with his six sons and one daughter farmed and raised families in that area. As the new West frontier opened up, the families migrated by rail, mostly to Illinois, Ohio, Michigan, Kansas, Texas and then some on to California, Oregon and Washington. Newspaper accounts of everyday life events and obituaries of their deaths are included. Hundreds of photographs of these Prindle/Prindel descendants, their homes, and headstones, along with some rare historical documents and maps have also been introduced into this book. These Prindles married into many other families during the past 250 years. Two surnames in particular stand out; the Goodwins and the Daddows. These surnames are given extra attention and are followed for a couple of generations. Personal accounts of living experiences and remembrances of some Prindle/Prindel family members are shared. Also mentioned in the book is a brief explanation of the surname Prindle; where it originated, what its meaning is and how it has changed over the years.